Tetrahydrofuran → 5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

HRID 1131277Notes

Reaction equation

HRID 1131277 reaction equation
[CH3:18][Si:19]([CH3:20])([CH3:21])[N-:22][Si:23]([CH3:24])([CH3:25])[CH3:26].[CH3:1][O:2][c:3]1[c:4]([CH2:5][NH:6][c:7]2[n:8][cH:9][n:10][s:11]2)[cH:12][cH:13][c:14]([O:16][CH3:17])[cH:15]1.[Cl:28][c:29]1[c:30]([F:40])[cH:31][c:32]([F:39])[c:33]([S:35](=[O:36])(=[O:37])[Cl:38])[cH:34]1.[Li+:27].[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1>>[CH3:1][O:2][c:3]1[c:4]([CH2:5][N:6]([c:7]2[n:8][cH:9][n:10][s:11]2)[S:35]([c:33]2[c:32]([F:39])[cH:31][c:30]([F:40])[c:29]([Cl:28])[cH:34]2)(=[O:36])=[O:37])[cH:12][cH:13][c:14]([O:16][CH3:17])[cH:15]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 27735275-Chloro-2,4-difluorobenzenesulphonyl chlorideHCID 3280088Npc316347HCID 57732216N-(2,4-dimethoxybenzyl)-1,2,4-thiadiazol-5-amine

Product 1

HCID 594366145-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Sources & evidence

ORD record
ord-26958faa623b471b95a0f3e74c1d907a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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