Tetrahydrofuran → 4-[2-(1,1-Dioxo-1lambda6-thiomorpholine-4-carbonyl)-1-isopropyl-1H-indol-5-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

HRID 1131915Notes

Reaction equation

HRID 1131915 reaction equation
[C:24]([CH3:25])([CH3:26])([CH3:27])[O:28][C:29](=[O:30])[N:31]1[CH2:32][CH2:33][CH:34]([OH:37])[CH2:35][CH2:36]1.[O:1]=[S:2]1(=[O:23])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[c:10]2[n:11]([CH:20]([CH3:21])[CH3:22])[c:12]3[cH:13][cH:14][c:15]([OH:19])[cH:16][c:17]3[cH:18]2)[CH2:6][CH2:7]1.[O:57]1[CH2:58][CH2:59][CH2:60][CH2:61]1.[c:38]1([P:39]([c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[cH:52][cH:53][cH:54][cH:55][cH:56]1>>[O:1]=[S:2]1(=[O:23])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[c:10]2[n:11]([CH:20]([CH3:21])[CH3:22])[c:12]3[cH:13][cH:14][c:15]([O:19][CH:34]4[CH2:33][CH2:32][N:31]([C:29]([O:28][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:30])[CH2:36][CH2:35]4)[cH:16][c:17]3[cH:18]2)[CH2:6][CH2:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 67073360(1,1-Dioxo-1lambda6-thiomorpholin-4-yl)-(5-hydroxy-1-isopropyl-1H-indol-2-yl)-methanone

Product 1

HCID 670734974-[2-(1,1-Dioxo-1lambda6-thiomorpholine-4-carbonyl)-1-isopropyl-1H-indol-5-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-1ca3ff37e09848c281cab8c418207bbc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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