Water → 2-[6-(3-[1-Adamantyl]-4-methoxyphenyl)-2-naphthyl]-2-hydroxy-acetonitrile

HRID 1133269Notes

Reaction equation

HRID 1133269 reaction equation
[C:1]12([c:11]3[cH:12][c:13](-[c:19]4[cH:20][c:21]5[cH:22][cH:23][c:24]([CH:29]=[O:30])[cH:25][c:26]5[cH:27][cH:28]4)[cH:14][cH:15][c:16]3[O:17][CH3:18])[CH2:2][CH:3]3[CH2:4][CH:5]([CH2:6][CH:7]([CH2:8]1)[CH2:9]3)[CH2:10]2.[CH3:31][Si:32]([CH3:33])([CH3:34])[C:35]#[N:36].[Cl:38][CH2:39][Cl:40].[I-:41].[I-:43].[OH2:37].[Zn+2:42]>>[C:1]12([c:11]3[cH:12][c:13](-[c:19]4[cH:20][c:21]5[cH:22][cH:23][c:24]([CH:29]([OH:30])[C:35]#[N:36])[cH:25][c:26]5[cH:27][cH:28]4)[cH:14][cH:15][c:16]3[O:17][CH3:18])[CH2:2][CH:3]3[CH2:4][CH:5]([CH2:6][CH:7]([CH2:8]1)[CH2:9]3)[CH2:10]2

Participants

7

Reactant 6

HCID 962WaterHCID 6344DichloromethaneHCID 30165Iodide Ion2×HCID 32051Zinc(2+)HCID 82115Trimethylsilyl cyanideHCID 865860366-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthaldehyde

Product 1

HCID 865860482-[6-(3-[1-Adamantyl]-4-methoxyphenyl)-2-naphthyl]-2-hydroxy-acetonitrile

Sources & evidence

ORD record
ord-0d991c9afc0b4fae9ef88f0a069a30b1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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