Hydrochloric Acid → tert-Butyl 4-(((6-methoxy-4-oxo-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylate

HRID 1133285Notes

Reaction equation

HRID 1133285 reaction equation
[CH3:23][c:24]1[cH:25][cH:26][c:27]([S:28]([O:29][CH2:34][CH:35]2[CH2:36][CH2:37][N:38]([C:41](=[O:42])[O:43][C:44]([CH3:45])([CH3:46])[CH3:47])[CH2:39][CH2:40]2)(=[O:30])=[O:31])[cH:32][cH:33]1.[ClH:48].[O:49]=[CH:50][N:51]([CH3:52])[CH3:53].[OH:1][c:2]1[c:3]([O:21][CH3:22])[cH:4][c:5]2[c:6](=[O:20])[n:7]([CH2:12][O:13][C:14]([C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[cH:8][n:9][c:10]2[cH:11]1>>[O:1]([c:2]1[c:3]([O:21][CH3:22])[cH:4][c:5]2[c:6](=[O:20])[n:7]([CH2:12][O:13][C:14]([C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[cH:8][n:9][c:10]2[cH:11]1)[CH2:34][CH:35]1[CH2:36][CH2:37][N:38]([C:41](=[O:42])[O:43][C:44]([CH3:45])([CH3:46])[CH3:47])[CH2:39][CH2:40]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 106428511-(tert-Butoxycarbonyl)-4-((p-toluenesulfonyloxy)methyl)piperidineHCID 10804576(7-Hydroxy-6-methoxy-4-oxoquinazolin-3(4H)-yl)methyl pivalate

Product 1

HCID 11733854tert-Butyl 4-(((6-methoxy-4-oxo-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-a31a41af5c49441cb79901fc66f931f9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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