Dimethylformamide → 4-Amino-N-[1-(2-hydroxyethyl)-4-piperidinyl]-3-methoxybenzamide

HRID 1133502Notes

Reaction equation

HRID 1133502 reaction equation
[CH3:32][N:33]([CH3:34])[CH:35]=[O:36].[CH3:37][CH2:38][N:39]([CH2:40][CH3:41])[CH2:42][CH3:43].[Cl:44][CH2:45][Cl:46].[NH2:1][CH:2]1[CH2:3][CH2:4][N:5]([CH2:8][CH2:9][OH:10])[CH2:6][CH2:7]1.[n:11]1([O:20][C:21](=[O:12])[c:22]2[cH:23][c:24]([O:29][CH3:30])[c:25]([NH2:28])[cH:26][cH:27]2)[c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[n:19][n:31]1>>[NH:1]([CH:2]1[CH2:3][CH2:4][N:5]([CH2:8][CH2:9][OH:10])[CH2:6][CH2:7]1)[C:21](=[O:20])[c:22]1[cH:23][c:24]([O:29][CH3:30])[c:25]([NH2:28])[cH:26][cH:27]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 106606854-Amino-3-methoxy-benzoic acid benzotriazol-1-yl esterHCID 157334452-(4-Aminopiperidin-1-yl)ethan-1-ol

Product 1

HCID 580150034-Amino-N-[1-(2-hydroxyethyl)-4-piperidinyl]-3-methoxybenzamide

Sources & evidence

ORD record
ord-6320c57691534e3b9be73d62e0e511de
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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