Dichloromethane → 3-(2,2-difluoro-6-hydroxy-1,3-benzodioxol-5-yl)-1-{[5-(trifluoromethyl)furan-2-yl]methyl}-1,3-dihydro-2H-indol-2-one

HRID 113567Notes

Reaction equation

HRID 113567 reaction equation
[CH2:34]([SiH:35]([CH2:36][CH3:37])[CH2:38][CH3:39])[CH3:40].[Cl:48][CH2:49][Cl:50].[F:1][C:2]1([F:33])[O:3][c:4]2[c:5]([cH:7][c:8]([OH:32])[c:9]([C:11]3([OH:31])[C:12](=[O:30])[N:13]([CH2:20][c:21]4[o:22][c:23]([C:26]([F:27])([F:28])[F:29])[cH:24][cH:25]4)[c:14]4[cH:15][cH:16][cH:17][cH:18][c:19]43)[cH:10]2)[O:6]1.[OH:41][C:42]([C:43]([F:44])([F:45])[F:46])=[O:47]>>[F:1][C:2]1([F:33])[O:3][c:4]2[c:5]([cH:7][c:8]([OH:32])[c:9]([CH:11]3[C:12](=[O:30])[N:13]([CH2:20][c:21]4[o:22][c:23]([C:26]([F:27])([F:28])[F:29])[cH:24][cH:25]4)[c:14]4[cH:15][cH:16][cH:17][cH:18][c:19]43)[cH:10]2)[O:6]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 673577963-(2,2-difluoro-6-hydroxy-1,3-benzodioxol-5-yl)-3-hydroxy-1-{[5-(trifluoromethyl)furan-2-yl]methyl}-1,3-dihydro-2H-indol-2-one

Product 1

HCID 673564293-(2,2-difluoro-6-hydroxy-1,3-benzodioxol-5-yl)-1-{[5-(trifluoromethyl)furan-2-yl]methyl}-1,3-dihydro-2H-indol-2-one

Sources & evidence

ORD record
ord-71adcf2928eb48c0ba8f9579cd1d5ad3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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