Sodium ion → 4-[6-(5-Chloro-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

HRID 1135728Notes

Reaction equation

HRID 1135728 reaction equation
[C:13]([CH3:14])([CH3:15])([CH3:16])[O:17][C:18](=[O:19])[N:20]1[CH2:21][CH2:22][CH:23]([O:26][c:27]2[n:28][cH:29][n:30][c:31]([Cl:33])[cH:32]2)[CH2:24][CH2:25]1.[CH3:39][CH2:40][O:41][C:42](=[O:43])[CH3:44].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([n:7]1)[CH2:8][CH2:9][NH:10]2.[H-:12].[Na+:11].[O:34]=[CH:35][N:36]([CH3:37])[CH3:38]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([n:7]1)[CH2:8][CH2:9][N:10]2[c:31]1[n:30][cH:29][n:28][c:27]([O:26][CH:23]2[CH2:22][CH2:21][N:20]([C:18]([O:17][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:19])[CH2:25][CH2:24]2)[cH:32]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 166653HydrideHCID 208229195-Chloro-2,3-dihydro-1H-pyrrolo[3,2-B]pyridineHCID 21906116tert-Butyl 4-[(6-chloropyrimidin-4-yl)oxy]piperidine-1-carboxylate

Product 1

HCID 498486624-[6-(5-Chloro-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-cf2bf7b632b54f1788e494db580a2a00
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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