Formamide → 2-Pyridinecarboxamide

HRID 1137112Notes

Reaction equation

HRID 1137112 reaction equation
[CH3:11][N:12]([CH3:13])[c:14]1[cH:15][cH:16][n:17][cH:18][cH:19]1.[CH3:61][C:62]#[N:63].[CH:23]1([P:24]([CH:25]2[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]2)[CH:31]2[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]2)[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]1.[CH:42]1([P:43]([CH:44]2[CH2:45][CH2:46][CH2:47][CH2:48][CH2:49]2)[CH:50]2[CH2:51][CH2:52][CH2:53][CH2:54][CH2:55]2)[CH2:56][CH2:57][CH2:58][CH2:59][CH2:60]1.[CH:8](=[O:9])[NH2:10].[Cl:1][c:2]1[cH:3][cH:4][cH:5][cH:6][n:7]1.[Pd:20]([Cl:21])[Cl:22]>>[c:2]1([C:8](=[O:9])[NH2:10])[cH:3][cH:4][cH:5][cH:6][n:7]1

Participants

7

Reactant 6

HCID 713FormamideHCID 6342AcetonitrileHCID 79772-ChloropyridineHCID 142844-(Dimethylamino)pyridineHCID 24290Palladium ChlorideHCID 75806Tricyclohexylphosphine2×

Product 1

HCID 150702-Pyridinecarboxamide

Sources & evidence

ORD record
ord-432f4536a426456f869596130d156f67
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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