Dimethylformamide → {{8-[5-(4-Fluorophenyl)-2-pentyl]-10-hydroxy-5,5-dimethyl-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridin-2-yl}acetyl}urea

HRID 1138144Notes

Reaction equation

HRID 1138144 reaction equation
[CH3:38][CH2:39][N:40]([CH2:41][CH3:42])[CH2:43][CH3:44].[CH3:45][N:46]([CH3:47])[CH:48]=[O:49].[Cl:1][CH2:2][C:3](=[O:4])[NH:5][C:6](=[O:7])[NH2:8].[F:9][c:10]1[cH:11][cH:12][c:13]([CH2:16][CH2:17][CH2:18][CH:19]([CH3:20])[c:21]2[cH:22][c:23]3[c:24]([c:25]([OH:27])[cH:26]2)[C:28]2=[C:33]([CH2:32][CH2:31][NH:30][CH2:29]2)[C:34]([CH3:36])([CH3:37])[O:35]3)[cH:14][cH:15]1>>[CH2:2]([C:3](=[O:4])[NH:5][C:6](=[O:7])[NH2:8])[N:30]1[CH2:29][C:28]2=[C:33]([CH2:32][CH2:31]1)[C:34]([CH3:36])([CH3:37])[O:35][c:23]1[cH:22][c:21]([CH:19]([CH2:18][CH2:17][CH2:16][c:13]3[cH:12][cH:11][c:10]([F:9])[cH:15][cH:14]3)[CH3:20])[cH:26][c:25]([OH:27])[c:24]12

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 78516(2-Chloroacetyl)ureaHCID 128007415,5-dimethyl-8-[5-(4-fluorophenyl)-2-pentyl]-10-hydroxy-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d]pyridine

Product 1

HCID 44327286{{8-[5-(4-Fluorophenyl)-2-pentyl]-10-hydroxy-5,5-dimethyl-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridin-2-yl}acetyl}urea

Sources & evidence

ORD record
ord-48db29899ca14b429c9be78085686752
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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