Tetrahydrofuran → tert-Butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate

HRID 1139233Notes

Reaction equation

HRID 1139233 reaction equation
[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH:23]([N:24]([CH2:25][CH3:26])[CH:27]([CH3:28])[CH3:29])([CH3:30])[CH3:31].[Cl:1][c:2]1[n:3][c:4]([CH3:9])[n:5][c:6]([Cl:8])[cH:7]1.[N:10]1([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1>>[c:2]1([N:13]2[CH2:12][CH2:11][N:10]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:15][CH2:14]2)[n:3][c:4]([CH3:9])[n:5][c:6]([Cl:8])[cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 81531DiisopropylethylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 2349974,6-Dichloro-2-methylpyrimidine

Product 1

HCID 18697994tert-Butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-7239c4b25b2f41bb9530e7ff477d12e5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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