Dichloromethane → 5-(2-Phenoxymethylpyrrolidine-1-sulfonyl)isatin

HRID 1139336Notes

Reaction equation

HRID 1139336 reaction equation
[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[Cl:43][CH2:44][Cl:45].[O:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[CH2:8][CH:9]1[N:10]([C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[CH2:11][CH2:12][CH2:13]1.[O:28]=[C:29]1[NH:30][c:31]2[cH:32][cH:33][c:34]([S:39](=[O:40])(=[O:41])[Cl:42])[cH:35][c:36]2[C:37]1=[O:38].[OH:21][C:22]([C:23]([F:24])([F:25])[F:26])=[O:27]>>[O:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[CH2:8][CH:9]1[N:10]([S:39]([c:34]2[cH:33][cH:32][c:31]3[c:36]([cH:35]2)[C:37](=[O:38])[C:29](=[O:28])[NH:30]3)(=[O:40])=[O:41])[CH2:11][CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 8028TetrahydrofuranHCID 159089472,3-Dioxoindoline-5-sulfonyl chlorideHCID 18672066Tert-butyl 2-(phenoxymethyl)pyrrolidine-1-carboxylate

Product 1

HCID 186720675-(2-Phenoxymethylpyrrolidine-1-sulfonyl)isatin

Sources & evidence

ORD record
ord-34ac6715e3254bbeab489c459b460c5e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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