Tetrahydrofuran → 2-[[2-Fluoro-4-(trifluoromethyl)phenyl]methyl]-3,6-dimethoxy-5-propan-2-yl-2,5-dihydropyrazine
Reaction equation
[CH3:1][O:2][C:3]1=[N:8][CH2:7][C:6]([O:9][CH3:10])=[N:5][CH:4]1[CH:11]([CH3:12])[CH3:13].[F:19][c:20]1[c:21]([CH2:22][Br:23])[cH:24][cH:25][c:26]([C:28]([F:29])([F:30])[F:31])[cH:27]1.[Li:14][CH2:15][CH2:16][CH2:17][CH3:18].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1>>[CH3:1][O:2][C:3]1=[N:8][CH:7]([CH2:22][c:21]2[c:20]([F:19])[cH:27][c:26]([C:28]([F:29])([F:30])[F:31])[cH:25][cH:24]2)[C:6]([O:9][CH3:10])=[N:5][CH:4]1[CH:11]([CH3:12])[CH3:13]Participants
5
Sources & evidence
- ORD record
- ord-de97c9a1368b4eb5a24783f80d747c1b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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