Water → 2-(4-Chloro-phenyl)-5-{3-methoxy-4-[2-(3-oxo-morpholin-4-yl)-ethoxy]-phenyl}-5H-thiazolo[5,4-c]pyridin-4-one

HRID 1141927Notes

Reaction equation

HRID 1141927 reaction equation
[CH2:70]1[O:71][CH2:72][CH2:73][CH2:74]1.[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[s:9][c:10]3[c:11](=[O:26])[n:12](-[c:17]4[cH:18][c:19]([O:24][CH3:25])[c:20]([OH:23])[cH:21][cH:22]4)[cH:13][cH:14][c:15]3[n:16]2)[cH:6][cH:7]1.[O:56]=[C:57]([O:58][CH:59]([CH3:60])[CH3:61])[N:62]=[N:63][C:64]([O:65][CH:66]([CH3:67])[CH3:68])=[O:69].[OH2:75].[OH:27][CH2:28][CH2:29][N:30]1[C:31](=[O:36])[CH2:32][O:33][CH2:34][CH2:35]1.[c:37]1([P:38]([c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[cH:51][cH:52][cH:53][cH:54][cH:55]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[s:9][c:10]3[c:11](=[O:26])[n:12](-[c:17]4[cH:18][c:19]([O:24][CH3:25])[c:20]([O:23][CH2:28][CH2:29][N:30]5[C:31](=[O:36])[CH2:32][O:33][CH2:34][CH2:35]5)[cH:21][cH:22]4)[cH:13][cH:14][c:15]3[n:16]2)[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 962WaterHCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 152874004-(2-Hydroxyethyl)morpholin-3-oneHCID 575017652-(4-Chloro-phenyl)-5-(4-hydroxy-3-methoxy-phenyl)-5H-thiazolo[5,4-c]pyridin-4-one

Product 1

HCID 116991542-(4-Chloro-phenyl)-5-{3-methoxy-4-[2-(3-oxo-morpholin-4-yl)-ethoxy]-phenyl}-5H-thiazolo[5,4-c]pyridin-4-one

Sources & evidence

ORD record
ord-f8f1963a295647efbca7a1e277f458a9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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