Acetic Acid → 3-Bromo-6-fluoro-2-methoxybenzaldehyde

HRID 1142307Notes

Reaction equation

HRID 1142307 reaction equation
[Br:13][c:14]1[c:15]([O:21][CH3:22])[cH:16][c:17]([F:20])[cH:18][cH:19]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH3:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36].[CH3:43][C:44](=[O:45])[OH:46].[CH:23](=[O:24])[N:25]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1.[CH:6]([NH:7][CH:8]([CH3:9])[CH3:10])([CH3:11])[CH3:12].[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1.[OH2:42]>>[Br:13][c:14]1[c:15]([O:21][CH3:22])[c:16]([CH:23]=[O:24])[c:17]([F:20])[cH:18][cH:19]1

Participants

9

Reactant 8

HCID 176Acetic AcidHCID 962WaterHCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 8058HexaneHCID 174291-PiperidinecarboxaldehydeHCID 70180432-Bromo-5-fluoroanisoleHCID 178418339Butyllithium

Product 1

HCID 222610733-Bromo-6-fluoro-2-methoxybenzaldehyde

Sources & evidence

ORD record
ord-781d0ad51fc941ed84f1d0ebf95435c2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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