反应详情

5-Bromo-3-(t-butyloxycarbonyl)aminothiophene-2-carboxamide (0.76 g) was stirred in dichloromethane (30 ml). Trifluoroacetic acid (51 ml) was added, the solution was stirred at room temperature for 1 h, poured into saturated aqueous sodium hydrogen carbonate solution (200 ml) and extracted with dichloromethane (3×100 ml). The combined extracts were washed with brine (150 ml), dried (magnesium sulphate), filtered and evaporated to give a yellow solid (0.511 g).

1. extractionextracted with dichloromethane (3×100 ml)
2. washThe combined extracts were washed with brine (150 ml)
3. dry with materialdried (magnesium sulphate)
4. filtrationfiltered
5. customevaporated