Dimethylformamide → 3-(4-methyl-imidazol-1-yl)-N-{3-[3-(2-oxo-2,3-dihydro-1H-indol-6-yl)-ureido]-phenyl}-5-trifluoromethyl-benzamide

HRID 1142883Notes

Reaction equation

HRID 1142883 reaction equation
[CH3:22][c:23]1[n:24][cH:25][n:26](-[c:28]2[cH:29][c:30]([C:31](=[O:32])[OH:33])[cH:34][c:35]([C:37]([F:38])([F:39])[F:40])[cH:36]2)[cH:27]1.[CH:41]([N:42]([CH2:43][CH3:44])[CH:45]([CH3:46])[CH3:47])([CH3:48])[CH3:49].[NH2:1][c:2]1[cH:3][c:4]([NH:8][C:9](=[O:10])[NH:11][c:12]2[cH:13][cH:14][c:15]3[c:19]([cH:20]2)[NH:18][C:17](=[O:21])[CH2:16]3)[cH:5][cH:6][cH:7]1.[O:74]=[CH:75][N:76]([CH3:77])[CH3:78].[P-:50]([F:51])([F:52])([F:53])([F:54])([F:55])[F:56].[n:57]1([O:58][C:59]([N:60]([CH3:61])[CH3:62])=[N+:63]([CH3:64])[CH3:65])[c:66]2[n:67][cH:68][cH:69][cH:70][c:71]2[n:72][n:73]1>>[NH:1]([c:2]1[cH:3][c:4]([NH:8][C:9](=[O:10])[NH:11][c:12]2[cH:13][cH:14][c:15]3[c:19]([cH:20]2)[NH:18][C:17](=[O:21])[CH2:16]3)[cH:5][cH:6][cH:7]1)[C:31]([c:30]1[cH:29][c:28](-[n:26]2[cH:25][n:24][c:23]([CH3:22])[cH:27]2)[cH:36][c:35]([C:37]([F:38])([F:39])[F:40])[cH:34]1)=[O:32]

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 469002413-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acidHCID 59804327HCID 59804327, compound

Product 1

HCID 598043033-(4-methyl-imidazol-1-yl)-N-{3-[3-(2-oxo-2,3-dihydro-1H-indol-6-yl)-ureido]-phenyl}-5-trifluoromethyl-benzamide

Sources & evidence

ORD record
ord-7d61ae6ff1ab4b8d8baa04d304387cb1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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