Tetrahydrofuran → 4-(5-Chloro-2-(tetrahydro-2H-pyran-4-ylamino)pyridin-3-YL)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

HRID 1142994Notes

Reaction equation

HRID 1142994 reaction equation
[C:42](=[O:43])([O-:44])[O-:45].[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[Cl:8][c:9]1[cH:10][c:11](-[c:16]2[n:17][c:18]([N:23]([CH2:24][c:25]3[cH:26][cH:27][c:28]([O:31][CH3:32])[cH:29][cH:30]3)[CH2:33][c:34]3[cH:35][cH:36][c:37]([O:40][CH3:41])[cH:38][cH:39]3)[n:19][c:20]([CH3:22])[n:21]2)[c:12]([F:15])[n:13][cH:14]1.[Cs+:46].[Cs+:47].[O:1]1[CH2:2][CH2:3][CH:4]([NH2:7])[CH2:5][CH2:6]1>>[O:1]1[CH2:2][CH2:3][CH:4]([NH:7][c:12]2[c:11](-[c:16]3[n:17][c:18]([N:23]([CH2:24][c:25]4[cH:26][cH:27][c:28]([O:31][CH3:32])[cH:29][cH:30]4)[CH2:33][c:34]4[cH:35][cH:36][c:37]([O:40][CH3:41])[cH:38][cH:39]4)[n:19][c:20]([CH3:22])[n:21]3)[cH:10][c:9]([Cl:8])[cH:14][n:13]2)[CH2:5][CH2:6]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 4192234-AminotetrahydropyranHCID 666005044-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Product 1

HCID 666117944-(5-Chloro-2-(tetrahydro-2H-pyran-4-ylamino)pyridin-3-YL)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Sources & evidence

ORD record
ord-49925d2d859042bf93d79c14dd90cee4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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