Bromobenzene → 5-(2,5-difluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)phenyl)-3-methyl-2-(phenylamino)pyrimidin-4(3H)-one
Reaction equation
[Br:45][c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1.[CH3:36][N:37]([c:38]1[cH:39][cH:40][n:41][cH:42][cH:43]1)[CH3:44].[Cl:25][c:26]1[c:27]2[c:28]([n:29][cH:30][cH:31]1)[cH:32][c:33]([I:35])[s:34]2.[F:1][c:2]1[c:3](-[c:10]2[c:11](=[O:24])[n:12]([CH3:23])[c:13]([NH:16][c:17]3[cH:18][cH:19][cH:20][cH:21][cH:22]3)[n:14][cH:15]2)[cH:4][c:5]([F:9])[c:6]([OH:8])[cH:7]1>>[F:1][c:2]1[c:3](-[c:10]2[c:11](=[O:24])[n:12]([CH3:23])[c:13]([NH:16][c:17]3[cH:18][cH:19][cH:20][cH:21][cH:22]3)[n:14][cH:15]2)[cH:4][c:5]([F:9])[c:6]([O:8][c:26]2[c:27]3[c:28]([n:29][cH:30][cH:31]2)[cH:32][c:33]([I:35])[s:34]3)[cH:7]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-c85f83afdcee4b108e25f2f78baadbef
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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