Tetrahydrofuran → 3-[1-(p-Chlorobenzyl)-3-(t-butylthio)-5-(i-propyl)-indole-2-yl]-2,2-dimethylpropanol

HRID 114420Notes

Reaction equation

HRID 114420 reaction equation
[Al+3:35].[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[c:8]([CH2:24][C:25]([C:26](=[O:27])[O:28][CH3:29])([CH3:30])[CH3:31])[c:9]([S:19][C:20]([CH3:21])([CH3:22])[CH3:23])[c:10]3[cH:11][c:12]([CH:16]([CH3:17])[CH3:18])[cH:13][cH:14][c:15]23)[cH:32][cH:33]1.[H-:34].[H-:37].[H-:38].[H-:39].[Li+:36].[O:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[c:8]([CH2:24][C:25]([CH2:26][OH:27])([CH3:30])[CH3:31])[c:9]([S:19][C:20]([CH3:21])([CH3:22])[CH3:23])[c:10]3[cH:11][c:12]([CH:16]([CH3:17])[CH3:18])[cH:13][cH:14][c:15]23)[cH:32][cH:33]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 44389574Methyl 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoate

Product 1

HCID 150354093-[1-(p-Chlorobenzyl)-3-(t-butylthio)-5-(i-propyl)-indole-2-yl]-2,2-dimethylpropanol

Sources & evidence

ORD record
ord-d4148566fc944a1e9cf5fc1ff3cb10b2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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