Phthalimide → tert-Butyl 3-(4-bromophenyl)-1-(1,3-dioxoisoindolin-2-yl)propan-2-ylcarbamate

HRID 1144205Notes

Reaction equation

HRID 1144205 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][CH:9]([CH2:10][OH:11])[NH:12][C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[cH:6][cH:7]1.[O:20]=[C:21]1[NH:22][C:23](=[O:24])[c:25]2[cH:26][cH:27][cH:28][cH:29][c:30]21.[O:31]=[C:32]([O:33][CH:34]([CH3:35])[CH3:36])[N:37]=[N:38][C:39]([O:40][CH:41]([CH3:42])[CH3:43])=[O:44].[O:45]1[CH2:46][CH2:47][CH2:48][CH2:49]1>>[Br:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][CH:9]([CH2:10][N:22]2[C:21](=[O:20])[c:30]3[c:25]([cH:26][cH:27][cH:28][cH:29]3)[C:23]2=[O:24])[NH:12][C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6809PhthalimideHCID 8028TetrahydrofuranHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 57594209tert-Butyl 3-(4-bromophenyl)-1-hydroxypropan-2-ylcarbamate

Product 1

HCID 71304639tert-Butyl 3-(4-bromophenyl)-1-(1,3-dioxoisoindolin-2-yl)propan-2-ylcarbamate

Sources & evidence

ORD record
ord-acba32c5c7b94b16afd262bb16936ba9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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