Tetrahydrofuran → Tert-butyl 4-(7-bromo-2-chloroquinazolin-8-yloxy)piperidine-1-carboxylate

HRID 1144761Notes

Reaction equation

HRID 1144761 reaction equation
[Br:13][c:14]1[cH:15][cH:16][c:17]2[cH:18][n:19][c:20]([Cl:25])[n:21][c:22]2[c:23]1[OH:24].[CH2:59]1[O:60][CH2:61][CH2:62][CH2:63]1.[O:1]=[C:2]([O:3][CH2:4][CH3:5])[N:6]=[N:7][C:8]([O:9][CH2:10][CH3:11])=[O:12].[OH:26][CH:27]1[CH2:28][CH2:29][N:30]([C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[CH2:31][CH2:32]1.[c:40]1([P:41]([c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[cH:54][cH:55][cH:56][cH:57][cH:58]1>>[Br:13][c:14]1[cH:15][cH:16][c:17]2[cH:18][n:19][c:20]([Cl:25])[n:21][c:22]2[c:23]1[O:24][CH:27]1[CH2:28][CH2:29][N:30]([C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[CH2:31][CH2:32]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 591992277-Bromo-2-chloroquinazolin-8-ol

Product 1

HCID 59199246Tert-butyl 4-(7-bromo-2-chloroquinazolin-8-yloxy)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-8da09bd9d1db40029e396117ff315caf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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