Hydrochloric Acid → 2-chloro-N-(fluoren-9-yl)-5-fluoro-4-pyrimidineamine

HRID 1145026Notes

Reaction equation

HRID 1145026 reaction equation
[CH:25]([N:26]([CH:27]([CH3:28])[CH3:29])[CH2:30][CH3:31])([CH3:32])[CH3:33].[Cl:16][c:17]1[n:18][cH:19][c:20]([F:24])[c:21]([Cl:23])[n:22]1.[ClH:1].[NH2:2][CH:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2-[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21>>[NH:2]([CH:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2-[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)[c:21]1[c:20]([F:24])[cH:19][n:18][c:17]([Cl:16])[n:22]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 10671Fluoren-9-amineHCID 81531DiisopropylethylamineHCID 2507052,4-Dichloro-5-fluoropyrimidine

Product 1

HCID 220606362-chloro-N-(fluoren-9-yl)-5-fluoro-4-pyrimidineamine

Sources & evidence

ORD record
ord-958e3c80ede7420fab8c74353d67ccf4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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