Hydrogen Bromide → 1-(3-(Bromomethyl)-4-methoxy-5-methylphenyl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine
Reaction equation
[BrH:35].[C:36](=[O:37])([O-:38])[O-:39].[Cl:42][CH2:43][Cl:44].[NH2:1][C:2]1=[N:3][C:4]([c:12]2[cH:13][c:14](-[c:18]3[cH:19][n:20][cH:21][n:22][cH:23]3)[cH:15][cH:16][cH:17]2)([c:24]2[cH:25][c:26]([CH3:34])[c:27]([O:32][CH3:33])[c:28]([CH2:30][OH:31])[cH:29]2)[c:5]2[cH:6][cH:7][cH:8][c:9]([F:11])[c:10]21.[Na+:40].[Na+:41]>>[NH2:1][C:2]1=[N:3][C:4]([c:12]2[cH:13][c:14](-[c:18]3[cH:19][n:20][cH:21][n:22][cH:23]3)[cH:15][cH:16][cH:17]2)([c:24]2[cH:25][c:26]([CH3:34])[c:27]([O:32][CH3:33])[c:28]([CH2:30][Br:35])[cH:29]2)[c:5]2[cH:6][cH:7][cH:8][c:9]([F:11])[c:10]21Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-364e4e20f7ca4f42ba593110d7a6b842
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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