Chloride → Tert-butyl 2-(4-aminoquinazolin-6-yl)acetate

HRID 1146859Notes

Reaction equation

HRID 1146859 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([NH2:12])[n:6][cH:7][n:8][c:9]2[cH:10][cH:11]1.[C:14]([CH3:15])([CH3:16])([CH3:17])[O:18][C:19]([CH2:20][Zn+:21])=[O:22].[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH3:23][CH2:24][O:25][CH2:26][CH3:27].[Cl-:13].[O:35]=[C:36]([CH:37]=[CH:38][c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1)[CH:45]=[CH:46][c:47]1[cH:48][cH:49][cH:50][cH:51][cH:52]1.[O:53]=[C:54]([CH:55]=[CH:56][c:57]1[cH:58][cH:59][cH:60][cH:61][cH:62]1)[CH:63]=[CH:64][c:65]1[cH:66][cH:67][cH:68][cH:69][cH:70]1.[O:71]=[C:72]([CH:73]=[CH:74][c:75]1[cH:76][cH:77][cH:78][cH:79][cH:80]1)[CH:81]=[CH:82][c:83]1[cH:84][cH:85][cH:86][cH:87][cH:88]1.[Pd:33].[Pd:34]>>[c:2]1([CH2:20][C:19]([O:18][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:22])[cH:3][c:4]2[c:5]([NH2:12])[n:6][cH:7][n:8][c:9]2[cH:10][cH:11]1

Participants

8

Reactant 7

HCID 312ChlorideHCID 3283Diethyl EtherHCID 8028TetrahydrofuranHCID 23938Palladium2×HCID 95417Dibenzylidene acetone3×HCID 7289356-Bromoquinazolin-4-amineHCID 178451180HCID 178451180, compound

Product 1

HCID 57690924Tert-butyl 2-(4-aminoquinazolin-6-yl)acetate

Sources & evidence

ORD record
ord-0b84fbe8005e4b359a7279bedcf66d28
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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