Dimethylformamide → 5-bromo-1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indole

HRID 1147971Notes

Reaction equation

HRID 1147971 reaction equation
[Br:46][c:47]1[cH:48][c:49]2[c:53]([cH:54][cH:55]1)[NH:52][CH2:51][CH2:50]2.[CH3:56][N:57]([CH3:58])[CH:59]=[O:60].[CH:37]([N:38]([CH2:39][CH3:40])[CH:41]([CH3:42])[CH3:43])([CH3:44])[CH3:45].[F:1][c:2]1[c:3]([CH2:9][C:10](=[O:11])[OH:12])[cH:4][c:5]([F:8])[cH:6][cH:7]1.[P-:13]([F:14])([F:15])([F:16])([F:17])([F:18])[F:19].[n:20]1([O:21][C:22]([N:23]([CH3:24])[CH3:25])=[N+:26]([CH3:27])[CH3:28])[c:29]2[n:30][cH:31][cH:32][cH:33][c:34]2[n:35][n:36]1>>[F:1][c:2]1[c:3]([CH2:9][C:10](=[O:12])[N:52]2[CH2:51][CH2:50][c:49]3[cH:48][c:47]([Br:46])[cH:55][cH:54][c:53]32)[cH:4][c:5]([F:8])[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 5228232,5-Difluorophenylacetic acidHCID 34115665-BromoindolineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium

Product 1

HCID 668238625-bromo-1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indole

Sources & evidence

ORD record
ord-6aab6eec5fbe44e7b138826615674f68
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…