Aniline → HCID 178418983, compound

HRID 11489Notes

Reaction equation

HRID 11489 reaction equation
O[CH:2]=[C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]1=[O:12].[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>O1CCCC1>[C:14]1([NH:13][CH:2]=[C:3]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[NH:5][C:4]2=[O:12])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 6115AnilineHCID 1784187413-(hydroxymethylidene)-1H-indol-2-one

Product 1

HCID 178418983HCID 178418983, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

E & Z 3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one is reacted with 0.022 gms. of aniline by refluxing in tetrahydrofuran (1.2 mL) for 12 hours to yield a quantitative amount (39 mg) of the named compound as a solid following concentration in vacuo, dilution with isopropanol and filtration.

Workup

  1. customto yield
  2. concentrationa quantitative amount (39 mg) of the named compound as a solid following concentration in vacuo, dilution
  3. filtrationwith isopropanol and filtration

Sources & evidence

ORD record
ord-18311b9ff0854255a339b2693026a150
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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