1,4-Dioxane → tert-butyl 4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyrimidin-2-yl]-3-[(N-methylsulfonylanilino)methyl]piperazine-1-carboxylate
Reaction equation
[CH2:52]1[O:53][CH2:54][CH2:55][O:56][CH2:57]1.[CH3:1][S:2](=[O:3])(=[O:4])[N:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[CH2:12][CH:13]1[CH2:14][N:15]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:16][CH2:17][NH:18]1.[CH:43]([N:44]([CH2:45][CH3:46])[CH:47]([CH3:48])[CH3:49])([CH3:50])[CH3:51].[Cl:26][c:27]1[n:28][cH:29][c:30]([C:33]([C:34]([F:35])([F:36])[F:37])([C:38]([F:39])([F:40])[F:41])[OH:42])[cH:31][n:32]1>>[CH3:1][S:2](=[O:3])(=[O:4])[N:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[CH2:12][CH:13]1[CH2:14][N:15]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:16][CH2:17][N:18]1[c:27]1[n:28][cH:29][c:30]([C:33]([C:34]([F:35])([F:36])[F:37])([C:38]([F:39])([F:40])[F:41])[OH:42])[cH:31][n:32]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-b7bf0318da914af1b5923d74ea98461e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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