Triethylamine → benzyl 2-[3-{[3-({2-[(tert-butoxycarbonyl)amino]ethoxy}methyl)phenethyl]amino}-5-chloro-6-methyl-2-oxo-1(2H)-pyrazinyl]acetate

HRID 1150226Notes

Reaction equation

HRID 1150226 reaction equation
[CH3:43][CH2:44][N:45]([CH2:46][CH3:47])[CH2:48][CH3:49].[CH3:50][CH2:51][O:52][C:53](=[O:54])[CH3:55].[Cl:22][c:23]1[c:24]([CH3:42])[n:25]([CH2:31][C:32](=[O:33])[O:34][CH2:35][c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[c:26](=[O:30])[c:27]([Cl:29])[n:28]1.[NH2:1][CH2:2][CH2:3][c:4]1[cH:5][c:6]([CH2:7][O:8][CH2:9][CH2:10][NH:11][C:12]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:18])[cH:19][cH:20][cH:21]1>>[NH:1]([CH2:2][CH2:3][c:4]1[cH:5][c:6]([CH2:7][O:8][CH2:9][CH2:10][NH:11][C:12]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:18])[cH:19][cH:20][cH:21]1)[c:27]1[c:26](=[O:30])[n:25]([CH2:31][C:32](=[O:33])[O:34][CH2:35][c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[c:24]([CH3:42])[c:23]([Cl:22])[n:28]1

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 10663926Benzyl 2-[3,5-dichloro-2-methyl-6-oxo-1(6H)-pyrazinyl]acetateHCID 18470932tert-Butyl 2-{[3-(2-aminoethyl)benzyl]oxy}ethylcarbamate

Product 1

HCID 18470846benzyl 2-[3-{[3-({2-[(tert-butoxycarbonyl)amino]ethoxy}methyl)phenethyl]amino}-5-chloro-6-methyl-2-oxo-1(2H)-pyrazinyl]acetate

Sources & evidence

ORD record
ord-0779d966ac534effbb43fc4995bad46f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…