Dimethylformamide → Tert-butyl 3-[({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl) (methyl)amino]-3-[(methylamino)carbonyl]azetidine-1-carboxylate
Reaction equation
[CH3:10][NH:11][C:12]1([C:23](=[O:24])[NH:25][CH3:26])[CH2:13][N:14]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:15]1.[CH:1]([N:2]([CH:3]([CH3:4])[CH3:5])[CH2:6][CH3:7])([CH3:8])[CH3:9].[Cl:27][c:28]1[c:29]([F:49])[c:30]([NH:34][c:35]2[n:36][cH:37][n:38][c:39]3[cH:40][c:41]([O:47][CH3:48])[c:42]([CH2:45][Cl:46])[cH:43][c:44]23)[cH:31][cH:32][cH:33]1.[O:50]=[CH:51][N:52]([CH3:53])[CH3:54]>>[CH3:10][N:11]([C:12]1([C:23](=[O:24])[NH:25][CH3:26])[CH2:13][N:14]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:15]1)[CH2:45][c:42]1[c:41]([O:47][CH3:48])[cH:40][c:39]2[n:38][cH:37][n:36][c:35]([NH:34][c:30]3[c:29]([F:49])[c:28]([Cl:27])[cH:33][cH:32][cH:31]3)[c:44]2[cH:43]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-2fb8da3eb02d4d9782e633f526e2a0ac
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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