Hydrochloric Acid → Bumetanide Impurity 118

HRID 1150462Notes

Reaction equation

HRID 1150462 reaction equation
[C:1](=[O:2])([O-:3])[O-:4].[CH3:7][c:8]1[cH:9][cH:10][c:11]([OH:12])[cH:13][cH:14]1.[Cl:15][c:16]1[c:17]([S:28](=[O:29])(=[O:30])[NH2:31])[cH:18][c:19]([C:25](=[O:26])[OH:27])[cH:20][c:21]1[N+:22](=[O:23])[O-:24].[ClH:32].[K+:5].[K+:6].[OH2:33]>>[CH3:7][c:8]1[cH:9][cH:10][c:11]([O:12][c:16]2[c:17]([S:28](=[O:29])(=[O:30])[NH2:31])[cH:18][c:19]([C:25](=[O:26])[OH:27])[cH:20][c:21]2[N+:22](=[O:23])[O-:24])[cH:13][cH:14]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 813Potassium Cation2×HCID 962WaterHCID 2879P-CresolHCID 19660Carbonate IonHCID 898934-Chloro-3-nitro-5-sulphamoylbenzoic acid

Product 1

HCID 21312073Bumetanide Impurity 118

Sources & evidence

ORD record
ord-fd215ddacb7c4d4ba01a133cfc14a0ef
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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