Acetate → Methyl 4-[2-[(5-methylfuran-2-yl)methylamino]quinolin-5-yl]but-3-enoate

HRID 1150751Notes

Reaction equation

HRID 1150751 reaction equation
[Br:1][c:2]1[c:3]2[cH:4][cH:5][c:6]([NH:12][CH2:13][c:14]3[o:15][c:16]([CH3:19])[cH:17][cH:18]3)[n:7][c:8]2[cH:9][cH:10][cH:11]1.[C:39]([O-:40])(=[O:41])[CH3:42].[C:44]([O-:45])(=[O:46])[CH3:47].[CH3:20][CH2:21][N:22]([CH2:23][CH3:24])[CH2:25][CH3:26].[CH3:27][O:28][C:29]([CH2:30][CH:31]=[CH2:32])=[O:33].[CH3:34][N:35]([CH3:36])[CH:37]=[O:38].[Pd+2:43]>>[c:2]1([CH:32]=[CH:31][CH2:30][C:29]([O:28][CH3:27])=[O:33])[c:3]2[cH:4][cH:5][c:6]([NH:12][CH2:13][c:14]3[o:15][c:16]([CH3:19])[cH:17][cH:18]3)[n:7][c:8]2[cH:9][cH:10][cH:11]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 6228DimethylformamideHCID 8471TriethylamineHCID 77314Methyl 3-butenoateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 67333430(5-Bromo-quinolin-2-yl)-(5-methyl-furan-2-ylmethyl)-amine

Product 1

HCID 67332244Methyl 4-[2-[(5-methylfuran-2-yl)methylamino]quinolin-5-yl]but-3-enoate

Sources & evidence

ORD record
ord-9f8e7d925c6f435baec43f9f090e2aee
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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