1-Bromo-3-fluorobenzene → Methyl 8-[1-(3-fluorophenyl)pyrrolidin-2-yl]-2-morpholin-4-yl-4-oxochromene-6-carboxylate

HRID 1151339Notes

Reaction equation

HRID 1151339 reaction equation
[Br:27][c:28]1[cH:29][c:30]([F:34])[cH:31][cH:32][cH:33]1.[C:35](=[O:36])([O-:37])[O-:38].[C:47]([O:48][Pd:49][O:50][C:51](=[O:52])[CH3:53])(=[O:54])[CH3:55].[CH2:41]1[O:42][CH2:43][CH2:44][O:45][CH2:46]1.[Cs+:39].[Cs+:40].[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[o:8][c:9]3[c:10]([CH:22]4[NH:23][CH2:24][CH2:25][CH2:26]4)[cH:11][c:12]([C:18](=[O:19])[O:20][CH3:21])[cH:13][c:14]3[c:15](=[O:17])[cH:16]2)[CH2:5][CH2:6]1>>[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[o:8][c:9]3[c:10]([CH:22]4[N:23]([c:28]5[cH:29][c:30]([F:34])[cH:31][cH:32][cH:33]5)[CH2:24][CH2:25][CH2:26]4)[cH:11][c:12]([C:18](=[O:19])[O:20][CH3:21])[cH:13][c:14]3[c:15](=[O:17])[cH:16]2)[CH2:5][CH2:6]1

Participants

7

Reactant 6

HCID 140821-Bromo-3-fluorobenzeneHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 167845palladium(II) acetateHCID 86672405methyl 2-morpholino-4-oxo-8-(pyrrolidin-2-yl)-4H-chromene-6-carboxylate

Product 1

HCID 89051670Methyl 8-[1-(3-fluorophenyl)pyrrolidin-2-yl]-2-morpholin-4-yl-4-oxochromene-6-carboxylate

Sources & evidence

ORD record
ord-6e74c45543124870a4fdc3d83c1a55a9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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