Sodium ion → 3',4'-difluoro-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)biphenyl-4-carboxamide
Reaction equation
[F:27][c:28]1[cH:29][c:30]([B:35]([OH:36])[OH:37])[cH:31][cH:32][c:33]1[F:34].[Na+:38].[Na+:39].[O-:40][C:41](=[O:42])[O-:43].[O:22]=[CH:23][N:24]([CH3:25])[CH3:26].[OH2:121].[OH:1][CH:2]1[CH2:3][CH2:4][c:5]2[cH:6][cH:7][cH:8][c:9]([NH:12][C:13]([c:14]3[cH:15][cH:16][c:17]([I:20])[cH:18][cH:19]3)=[O:21])[c:10]2[CH2:11]1.[Pd:44].[c:102]1([P:103]([c:104]2[cH:105][cH:106][cH:107][cH:108][cH:109]2)[c:110]2[cH:111][cH:112][cH:113][cH:114][cH:115]2)[cH:116][cH:117][cH:118][cH:119][cH:120]1.[c:45]1([P:46]([c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)[cH:59][cH:60][cH:61][cH:62][cH:63]1.[c:64]1([P:65]([c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[c:72]2[cH:73][cH:74][cH:75][cH:76][cH:77]2)[cH:78][cH:79][cH:80][cH:81][cH:82]1.[c:83]1([P:84]([c:85]2[cH:86][cH:87][cH:88][cH:89][cH:90]2)[c:91]2[cH:92][cH:93][cH:94][cH:95][cH:96]2)[cH:97][cH:98][cH:99][cH:100][cH:101]1>>[OH:1][CH:2]1[CH2:3][CH2:4][c:5]2[cH:6][cH:7][cH:8][c:9]([NH:12][C:13]([c:14]3[cH:15][cH:16][c:17](-[c:30]4[cH:29][c:28]([F:27])[c:33]([F:34])[cH:32][cH:31]4)[cH:18][cH:19]3)=[O:21])[c:10]2[CH2:11]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-c98aa03bf2ab4db793f7a7b7ac52d8f1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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