Tetrahydrofuran → Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate

HRID 1151480Notes

Reaction equation

HRID 1151480 reaction equation
[Al+3:20].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([C:14](=[O:15])[O:16][CH2:17][CH3:18])[CH2:12][CH2:13]1.[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[H-:19].[H-:22].[H-:23].[H-:24].[Li+:21]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][OH:15])[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 27588121-Tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

Product 1

HCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-7a10539fc9f843829d0189ff31a39655
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…