Dichloromethane → 7-Chloro-2-(4-methoxyphenylthiocarbamoyl)-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylic acid amide

HRID 1152281Notes

Reaction equation

HRID 1152281 reaction equation
[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[CH3:34][O:35][c:36]1[cH:37][cH:38][c:39]([N:42]=[C:43]=[S:44])[cH:40][cH:41]1.[Cl:45][CH2:46][Cl:47].[Cl:8][c:9]1[c:10]([C:24](=[O:25])[NH2:26])[c:11]2[n:12]([c:17]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH2:13][CH2:14][NH:15][CH2:16]2.[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[Cl:8][c:9]1[c:10]([C:24](=[O:25])[NH2:26])[c:11]2[n:12]([c:17]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH2:13][CH2:14][N:15]([C:43]([NH:42][c:39]1[cH:38][cH:37][c:36]([O:35][CH3:34])[cH:41][cH:40]1)=[S:44])[CH2:16]2

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 752934-Methoxyphenyl isothiocyanateHCID 68886671HCID 68886671, compound

Product 1

HCID 589881127-Chloro-2-(4-methoxyphenylthiocarbamoyl)-6-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylic acid amide

Sources & evidence

ORD record
ord-fca2bcae0ad94dbeb5d5a3c398b340f5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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