Tetrahydrofuran → 3-(3-Chloro-4-((pyrrolidin-1-yl)methyl)phenyl)-3-hydroxycyclobutanecarboxylic acid
Reaction equation
[Br:6][c:7]1[cH:8][c:9]([Cl:19])[c:10]([CH2:11][N:12]2[CH2:13][CH2:14][CH2:15][CH2:16]2)[cH:17][cH:18]1.[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH3:1][CH2:2][CH2:3][CH2:4][Li:5].[O:20]=[C:21]1[CH2:22][CH:23]([C:25](=[O:26])[OH:27])[CH2:24]1>>[c:7]1([C:21]2([OH:20])[CH2:22][CH:23]([C:25](=[O:26])[OH:27])[CH2:24]2)[cH:8][c:9]([Cl:19])[c:10]([CH2:11][N:12]2[CH2:13][CH2:14][CH2:15][CH2:16]2)[cH:17][cH:18]1Participants
5
Sources & evidence
- ORD record
- ord-b7d55457aa8142b9a0307f991003e26d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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