Dimethylformamide → 4-(2-((Tert-butyldimethylsilyloxy)methyl)pyridin-4-yloxy)-2-fluorobenzenamine

HRID 1152500Notes

Reaction equation

HRID 1152500 reaction equation
[C:25]([CH3:26])([CH3:27])([CH3:28])[Si:29]([CH3:30])([CH3:31])[Cl:32].[CH3:18][CH2:19][N:20]([CH2:21][CH3:22])[CH2:23][CH3:24].[NH2:1][c:2]1[c:3]([F:17])[cH:4][c:5]([O:6][c:7]2[cH:8][c:9]([CH2:13][OH:14])[n:10][cH:11][cH:12]2)[cH:15][cH:16]1.[O:33]=[CH:34][N:35]([CH3:36])[CH3:37]>>[NH2:1][c:2]1[c:3]([F:17])[cH:4][c:5]([O:6][c:7]2[cH:8][c:9]([CH2:13][O:14][Si:29]([C:25]([CH3:26])([CH3:27])[CH3:28])([CH3:30])[CH3:31])[n:10][cH:11][cH:12]2)[cH:15][cH:16]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 28928tert-Butyldimethylsilyl chlorideHCID 67253926HCID 67253926, compound

Product 1

HCID 672534314-(2-((Tert-butyldimethylsilyloxy)methyl)pyridin-4-yloxy)-2-fluorobenzenamine

Sources & evidence

ORD record
ord-5a5681e0c55b462c80b2a5062bb29b0b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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