Methanol → 3,4-dimethyl-6-(6-(2'-oxo-2',3'-dihydro-1'H-spiro[piperidin-4,4'-quinazolin]-1-yl)pyrimidin-4-carbonyl)benzo[d]oxazol-2(3H)-one

HRID 1153652Notes

Reaction equation

HRID 1153652 reaction equation
[CH3:52][OH:53].[CH:38]([N:39]([CH2:40][CH3:41])[CH:42]([CH3:43])[CH3:44])([CH3:45])[CH3:46].[Cl:17][c:18]1[cH:19][c:20]([C:24](=[O:25])[c:26]2[cH:27][c:28]3[c:29]([n:30]([CH3:34])[c:31](=[O:33])[o:32]3)[c:35]([CH3:37])[cH:36]2)[n:21][cH:22][n:23]1.[NH:1]1[C:2](=[O:16])[NH:3][C:4]2([CH2:5][CH2:6][NH:7][CH2:8][CH2:9]2)[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21.[O:47]=[CH:48][N:49]([CH3:50])[CH3:51]>>[NH:1]1[C:2](=[O:16])[NH:3][C:4]2([CH2:5][CH2:6][N:7]([c:18]3[cH:19][c:20]([C:24](=[O:25])[c:26]4[cH:27][c:28]5[c:29]([n:30]([CH3:34])[c:31](=[O:33])[o:32]5)[c:35]([CH3:37])[cH:36]4)[n:21][cH:22][n:23]3)[CH2:8][CH2:9]2)[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21

Participants

6

Reactant 5

HCID 887MethanolHCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 497603501'H-Spiro[piperidine-4,4'-quinazolin]-2'(3'H)-oneHCID 581811626-(6-chloropyrimidine-4-carbonyl)-3,4-dimethyl-3H-benzoxazol-2-one

Product 1

HCID 252652973,4-dimethyl-6-(6-(2'-oxo-2',3'-dihydro-1'H-spiro[piperidin-4,4'-quinazolin]-1-yl)pyrimidin-4-carbonyl)benzo[d]oxazol-2(3H)-one

Sources & evidence

ORD record
ord-c738cd418b1f486dadbde15c53bd62bf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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