Butyl bromide → HCID 20340027, compound

HRID 1153825Notes

Reaction equation

HRID 1153825 reaction equation
[Na].[CH2:2]([O:4][C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH:13]1[N:17]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[C:16](=[O:26])[NH:15][C:14]1=[O:27])=[O:6])[CH3:3].[CH2:28](Br)[CH2:29][CH2:30][CH3:31]>C(O)C>[CH2:28]([N:15]1[C:14](=[O:27])[CH:13]([CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:5]([O:4][CH2:2][CH3:3])=[O:6])[N:17]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[C:16]1=[O:26])[CH2:29][CH2:30][CH3:31]

Participants

5

Reactant 3

HCID 8002Butyl bromideHCID 5360545SodiumHCID 12788655HCID 12788655, compound

Product 1

HCID 20340027HCID 20340027, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of sodium (308 mg) in ethanol (40 ml) was added 5-(6-ethoxycarbonylhexyl)-1-octylhydantoin, followed by butyl bromide (1.8 g), and the solution was refluxed for 24 hours. The solvent was evaporated, water was added and the insoluble oil was extracted with ether. The washed and dried extract was evaporated to give 3-butyl-5-(6-ethoxycarbonylhexyl)-1-octyl hydantoin.

Workup

  1. temperaturethe solution was refluxed for 24 hours
  2. customThe solvent was evaporated
  3. additionwater was added
  4. extractionthe insoluble oil was extracted with ether
  5. washThe washed
  6. customdried
  7. extractionextract
  8. customwas evaporated

Sources & evidence

ORD record
ord-f335498f418344ff8898ebf0b850640d
Source dataset
uspto-grants-1984_12
Patent number
US04486443

Reaction notes

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