反应详情

A solution of 20.0 g of 6-[2-(1-pyrrolidinyl)ethylamino]-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine in 60 ml of 2-propanol was heated to reflux and 6 ml of concentrated hydrochloric acid was added slowly. An exothermic reaction took place and a white precipitate formed immediately. The mixture was refluxed for 30 minutes and then cooled. The solid was separated by filtration, washed thoroughly with 2-propanol and then dried at 50° C. under reduced pressure to give 6-[2-(1-pyrrolidinyl)ethylamino]-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine hydrochloride hydrate.

1. temperatureto reflux
2. customAn exothermic reaction
3. customa white precipitate formed immediately
4. temperatureThe mixture was refluxed for 30 minutes
5. temperaturecooled
6. customThe solid was separated by filtration
7. washwashed thoroughly with 2-propanol
8. customdried at 50° C. under reduced pressure