Hydrochloric Acid → 6-[3-(1-Pyrrolidinyl)propylamino]-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine dihydrochloride hemihydrate

HRID 1154021Notes

Reaction equation

HRID 1154021 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][NH:9][C:10]2[C:19]3[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=3[C:13]3=[N:20][N:21]=[CH:22][N:12]3[N:11]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:23].C([OH:26])C>>[OH2:26].[ClH:23].[ClH:23].[N:1]1([CH2:6][CH2:7][CH2:8][NH:9][C:10]2[C:19]3[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=3[C:13]3=[N:20][N:21]=[CH:22][N:12]3[N:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1.[N:1]1([CH2:6][CH2:7][CH2:8][NH:9][C:10]2[C:19]3[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=3[C:13]3=[N:20][N:21]=[CH:22][N:12]3[N:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1.[ClH:23].[ClH:23]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 133656006-[3-(1-Pyrrolidinyl)propylamino]-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine

Product 1

HCID 705037256-[3-(1-Pyrrolidinyl)propylamino]-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine dihydrochloride hemihydrate

Procedure

The amine obtained above was dissolved in ethanol and treated with an excess of ethereal hydrogen chloride. The solid which formed was separated by filtration to give 6-[3-(1-pyrrolidinyl)propylamino]-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine dihydrochloride hemihydrate melting at about 277°-278° C.

Workup

  1. customThe solid which formed
  2. customwas separated by filtration

Sources & evidence

ORD record
ord-c1c1568c8cbf45c0b3738e0c5c8a424e
Source dataset
uspto-grants-1984_12
Patent number
US04487930

Reaction notes

Loading…