Hydrochloric Acid → HCID 178460722, compound

HRID 1154027Notes

Reaction equation

HRID 1154027 reaction equation
Cl.Cl.[CH3:3][O:4][C:5]([NH:7][C:8]1[NH:12][C:11]2[CH:13]=[CH:14][C:15]([S:17](Cl)(=O)=O)=[CH:16][C:10]=2[N:9]=1)=[O:6].COC(NC1N[C:29]2C=CC(S)=[CH:34][C:28]=2N=1)=O>[Fe]>[CH3:3][O:4][C:5]([NH:7][C:8]1[NH:12][C:11]2[CH:13]=[CH:14][C:15]([S:17][CH2:29][CH2:28][CH3:34])=[CH:16][C:10]=2[N:9]=1)=[O:6]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 178502043HCID 178502043, compoundHCID 178502050HCID 178502050, compound

Product 1

HCID 178460722HCID 178460722, compound

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

Into 100 ml. of a 10% aqueous hydrochloric acid solution 10.8 g. (0.033 moles) of 2-[(methoxycarbonyl)amino]-1H-benzimidazole-5-sulfonic acid chloride hydrochloride and 10 g. of Fe powder are added at room temperature. The mixture is stirred at 70° to 80° C. for 5 hours, whereupon the precipitated 2-[(methoxycarbonyl)amino]-1H-benzimidazole-5-thiol is filtered off and converted into 2-[(methoxycarbonyl)amino]-5-propylthio-1H-benzimidazole as described in Example 10. The product melts at 208° to 210° C.

Workup

  1. filtrationis filtered off

Sources & evidence

ORD record
ord-3ca983d4cdc14213995deedb77915281
Source dataset
uspto-grants-1984_12
Patent number
US04487936

Reaction notes

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