反应详情

A mixture of 10.0 g. of N-[4-(1H-imidazol-1-yl)-butyl]isoindole-1,3(2H)-dione, 1.97 ml. of hydrazine hydrate and 100 ml. of ethanol was heated at reflux for 3 hours and then cooled. A 160 ml. of portion of 3N hydrochloric acid was added, the mixture was heated at reflux for one hour and then concentrated. The residue was stirred with 150 ml. of 3N hydrochloric acid and then filtered. The mother liquor was concentrated to dryness, diluted with 10 ml. of ethanol and cooled, giving 1H-imidazole-1-butanamine dihydrochloride (m.p. 132°-146° C.) which was recovered by filtration.

1. additionA mixture of 10.0 g
2. temperatureat reflux for 3 hours
3. temperaturecooled
4. temperaturethe mixture was heated
5. temperatureat reflux for one hour
6. concentrationconcentrated
7. filtrationof 3N hydrochloric acid and then filtered
8. concentrationThe mother liquor was concentrated to dryness
9. additiondiluted with 10 ml
10. temperatureof ethanol and cooled