反应详情

Phosphorus trichloride (1 mmol) is added to a solution of benzyl 6-azido-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylate (0.5 mmol) in anhydrous dimethylformamide (2.5 ml) and the mixture is left to stand at room temperature. After 5 hr, the mixture is diluted with toluene, washed with water, 1 N hydrochloric acid, 5% sodium bicarbonate solution, and brine, dried over magnesium sulfate, and filtered. Evaporation of the solvent under vacuum yields benzyl 6-azido-3-chloro-1-azabicyclo[3.2.0]-hept-2-en-7-one-2-carboxylate.

1. waitthe mixture is left
2. customto stand at room temperature
3. washwashed with water, 1 N hydrochloric acid, 5% sodium bicarbonate solution, and brine
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customEvaporation of the solvent under vacuum