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HRID1155440

反应详情

EQUATION

反应方程式

HRID 1155440 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：COc1ccccc1
HCID7519

Anisole

C7H8O

结构：COC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)[C@@H](NC(=O)COc3ccccc3)[C@H]2SC1
HCID6453042

N-{2-[(Diphenylmethoxy)carbonyl]-3-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl}-2-phenoxyethanimidic acid

C29H26N2O6S

PRODUCTS

生成物

1
结构：COC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)COc3ccccc3)[C@H]2SC1
HCID12784142

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

0.87 ml of anisole is added to a solution of 2.0 g (3.78 mmols) of 7β-phenoxyacetamido-3-methoxy-ceph-3-em-4-carboxylic acid diphenylmethyl ester in 5 ml of methylene chloride and the mixture is cooled to 0° C. and left to stand for 1 hour after adding 1.2 ml of trifluoroacetic acid. The reaction mixture is concentrated in vacuo and the residue is crystallised from acetone/ether. 7β-Phenoxyacetamido-3-methoxy-ceph-3-em-4-carboxylic acid of melting point 170° C. (decomposition) is obtained.

WORKUP

后处理

  1. waitleft
  2. concentrationThe reaction mixture is concentrated in vacuo
  3. customthe residue is crystallised from acetone/ether