反应详情

1.422 kg of 3,4,5-trimethoxy-phenylethylamine is slowly added to a mixture of 2.185 kg of 98% formic acid and 1.728 kg of acetic anhydride, while maintaining the temperature at about 50°. The reaction bath is maintained at this temperature for about 3 hours and the formic acid and acetic acid mixture and the excess anhydride is distilled. The formylated derivative thus obtained (1.734 kg) is used unpurified.

1. temperaturewhile maintaining the temperature at about 50°
2. temperatureThe reaction bath is maintained at this temperature for about 3 hours
3. distillationthe formic acid and acetic acid mixture and the excess anhydride is distilled
4. customThe formylated derivative thus obtained (1.734 kg)