Potassium Carbonate → 2-(1,4-BENXODIOXAN-2YL)-METHYLENE-IMIDAZOLE

HRID 1155517Notes

Reaction equation

HRID 1155517 reaction equation
Cl.[O:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][CH2:4][CH:3]1[CH2:12][C:13]1[NH:14][CH:15]=[CH:16][N:17]=1.C(=O)([O-])[O-].[K+].[K+]>CCOCC>[O:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][CH2:4][CH:3]1[CH2:12][C:13]1[NH:17][CH:16]=[CH:15][N:14]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 12761757HCID 12761757, compound

Product 1

HCID 127617562-(1,4-BENXODIOXAN-2YL)-METHYLENE-IMIDAZOLE

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2-(1,4-benzodioxan-2-ylmethyl)imidazole hydrochloride (1.0 g) suspended in 50 ml of ether is stirred with excess dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 2-(1,4-benzodioxan-2-ylmethyl)imidazole.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-d77029db7ac34289a69cb645ffd8aa88
Source dataset
uspto-grants-1981_11
Patent number
US04302469

Reaction notes

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