Hydrogen Bromide → HCID 136359195, compound

HRID 1155528Notes

Reaction equation

HRID 1155528 reaction equation
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7](=[S:15])[C:8]([CH3:14])=[CH:9][N:10]2[CH3:13])=[CH:5][CH:4]=1.Br.C(=O)(O)[O-].[Na+]>C(O)(=O)C>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7](=[S:15])[C:8]([CH3:14])=[CH:9][N:10]2[CH3:13])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 516892Sodium BicarbonateHCID 86738121HCID 86738121, compound

Product 1

HCID 136359195HCID 136359195, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 7-methoxy-1-methyl-3-methylthio-4-quinolone (8.23 g.) glacial acetic acid (75 ml.) and hydrobromic acid (75 ml.) was stirred and boiled under reflux for 2 days. The mixture was cooled and poured into saturated aqueous sodium bicarbonate (500 ml.). The resulting precipitate was collected by filtration and dried to give 7-hydroxy-1-methyl-3-methylthio-4-quinolone, m.p. 285°-288°.

Workup

  1. temperatureunder reflux for 2 days
  2. temperatureThe mixture was cooled
  3. filtrationThe resulting precipitate was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-b8d773b98b3d4873a3d1cd1e43f95c20
Source dataset
uspto-grants-1981_11
Patent number
US04302460

Reaction notes

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