Nitric Acid → HCID 13022565, compound

HRID 1155580Notes

Reaction equation

HRID 1155580 reaction equation
OS(O)(=O)=O.O=S(=O)=O.[N+:10]([O-:13])(O)=[O:11].[Br:14][C:15]1[CH:16]=[C:17]([CH:24]=[CH:25][CH:26]=1)[NH:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21]>>[Br:14][C:15]1[CH:16]=[C:17]([CH:24]=[CH:25][C:26]=1[N+:10]([O-:13])=[O:11])[NH:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 24681Fuming sulfuric acidHCID 1234458N-(3-bromophenyl)-2-methylpropanamide

Product 1

HCID 13022565HCID 13022565, compound

Procedure

Prepare a solution of 260 ml. of 30-33% oleum and 20 g. of 90% nitric acid. Cool the solution to 0° and add in small portion 60.5 g. of metabromo isobutyranilide. Maintain the reaction at 0°-5° C. for an additional 30 minutes with agitation. Isolate the product by the procedure described in Example 1 to obtain 3'-bromo-4'-nitro-isobutyranilide.

Workup

  1. customPrepare a solution of 260 ml
  2. temperatureCool the solution to 0°
  3. additionadd in small portion 60.5 g
  4. temperatureMaintain
  5. customthe reaction at 0°-5° C. for an additional 30 minutes with agitation
  6. customIsolate the product by the procedure

Sources & evidence

ORD record
ord-25fcc8e93d1040b9b4d030cf363f786a
Source dataset
uspto-grants-1981_11
Patent number
US04302599

Reaction notes

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