Hydrochloric Acid → 3-Chloro-3-cyano-2,2-dimethyl-propane-1-carboxylic acid ethyl ester
Reaction equation
[Cl:1]Cl.[CH2:3]([O:5][C:6]([CH2:8][C:9]([CH3:17])([CH3:16])[CH:10](C(O)=O)[C:11]#[N:12])=[O:7])[CH3:4].C([O-])(=O)C.[Na+].Cl>O>[CH2:3]([O:5][C:6]([CH2:8][C:9]([CH3:17])([CH3:16])[CH:10]([Cl:1])[C:11]#[N:12])=[O:7])[CH3:4]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
17.8 g (0.25 mol) of chlorine were passed into a solution of 42.6 g (0.2 mol) of 3-carboxy-3-cyano-2,2-dimethyl-propane-1-carboxylic acid ethyl ester and 41 g of sodium acetate in 400 ml of water at 20° C. The mixture was subsequently stirred at 20° C. for 5 hours and then acidified with dilute HCl. The acid solution was worked up as described under Example 1. 28 g (69% of theory) of 3-chloro-3-cyano-2,2-dimethyl-propane-1-carboxylic acid ethyl ester were obtained in the form of a colorless oil of boiling point 80°-82° C./1 mm Hg.
Sources & evidence
- ORD record
- ord-e6385e331edc40d2b9d9d481dbadaf5b
- Source dataset
- uspto-grants-1982_06
- Patent number
- US04332745
Reaction notes
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